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28 Alpha-casozepine
Average EDED Score 20 P<0.0001 Figure 2. Average EDED score of alpha-casozepine
24
Selegiline
and selegiline groups at initial visit and week 8.
16
The difference in EDED score between initial
visit and week 8 was significant for both groups.
12
8
4
Initial Visit Week 8
CONCLUSION & CLINICAL IMPORTANCE
Alpha-casozepine was equally effective in controlling anxiety as selegiline, an MAOI marketed for the
treatment of anxiety disorders and cognitive dysfunction in dogs. This study provides evidence for the
efficacy of alpha-casozepine in the management of dogs exhibiting behaviors attributable to anxiety.
Further, there were no reported side effects in dogs receiving alpha-casozepine.
SCIENTIFIC INSIGHTS SUMMARY
Stress is postulated to play an important role in the brain-gut-microbiome axis, and stress
reduction is recommended as a key component of multimodal management for dogs that are
experiencing stress or anxiety. Highly digestible foods containing prebiotic fiber and a stress-alleviating
ingredient, such as Hill’s® Prescription Diet® i/d® Stress, may improve abnormalities in the
brain-gut-microbiome axis and help manage dogs with stress-related gastrointestinal disorders.
REFERENCES
1 Honneffer JB, Minamoto Y, Suchodolski JS. Microbiota alterations in acute and chronic gastrointestinal
inflammation of cats and dogs. World Journal of Gastroenterology 2014;20(44):16489-16497.
2 Konturek PC, Brzozowski T, Konturek SJ. Stress and the gut: pathophysiology, clinical consequences,
diagnostic approach and treatment options. J Physiology and Pharmacology 2011;62(6):591-599.
3 Gibson GR and Roberfroid M, editors. Handbook of Prebiotics. Boca Raton, FL: Taylor & Francis Group,
2008;1-22.
4 Miclo L, Perrin E, Driou A, et al. Characterization of alpha-casozepine, a tryptic peptide from bovine
alpha-s1-casein with benzodiazepine-like activity. FASEB J. 2001;15(10):1780-1782.
5 Beata C, Beaumont-Graff E, Diaz C, et al. Effects of alpha-casozepine (Zylkene) versus selegiline
hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. J Vet Behavior. 2007;2(5):175-183.
6 Beata C, Beaumont-Graff E, Coll V, et al. Effect of alpha-casozepine (Zylkene) on anxiety in cats.
J Vet Behavior. 2007;2(2):40-46.
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