Page 8 - Diet And Dementia Casein Antioxidants DHEA

Fecal Bifidobacterium Fecal Lactobacillus
Group CFU log 10/g feces CFU log 10/g feces
Baseline 2 Weeks P-Value Baseline 2 Weeks P-Value

Prebiotic Fiber Blend 8.3 9.1 0.03 10.3 11.1 0.04
FortiFlora® ® 8.3 9.3 <0.01 10.3 11.3 0.01

Prostora® Max 8.3 9.6 <0.01 10.3 11.5 <0.01
™
Control 8.4 8.5 0.58 10.4 10.5 0.67

Table 1. Mean fecal Bifidobacterium and Lactobacillus concentrations for control food+prebiotic fiber blend, control food+FortiFlora®, control food+Prostora™ Max,
and control food groups at baseline and after 2 weeks of treatment. P-values represent the difference between baseline and 2 weeks.

Dogs were randomly assigned to either the
Effects of alpha-casozepine (Zylkene) alpha-casozepine (test) or selegiline group.
versus selegiline hydrochloride The test group received 15 mg/kg body weight
(Selgian, Anipryl) on anxiety (BW) of alpha-casozepine orally once a day,
disorders in dogs 5 while the selegiline group received 0.5 mg/kg
BW orally once a day. Dogs in both groups
were also provided behavioral modification.
STUDY OBJECTIVE Each dog was evaluated 5 times during the

The purpose of this study was to determine if 56-day study. Evaluations were performed
the natural biological agent alpha-casozepine initially and at weeks 4 and 8 in the hospital;
(hydrolyzed casein) has the same anxiolytic telephone evaluations occurred at weeks 2 and
effect as selegiline, a monoamine oxidase 6. Two separate categories were tracked at each
inhibitor (MAOI) used for the treatment of evaluation: EDED score and owner’s subjective
anxiety disorders and cognitive dysfunction evaluation of change. Positive results were
in dogs. defined as an EDED score < 20 and owner’s
subjective evaluation score ≥ 6/10. Successful
treatment had to meet both criteria.
STUDY DESIGN
This study was a multicenter, randomized, RESULTS
blinded, comparative trial. Dogs were
evaluated for anxiety by using a validated dog Thirty-eight dogs (19 female, 19 male)
emotional scale (Emotional Disorder Evaluation completed the study. Overall, there were 19
for Dogs or EDED). Dogs diagnosed with an successes: 10 dogs in the alpha-casozepine
anxiety-related behavior that had persisted group and 9 dogs in the selegiline group.
for >4 weeks and which had a total score of No significant difference existed between
>19 out of 45 points on the EDED scale were the two groups; alpha-casozepine &
included in the study. Owners subjectively selegiline were equally effective in treating
evaluated and scored their dog’s behavior anxiety based on both EDED scores and
throughout the study on a scale of -10 to 10. owners’ evaluations. There was a significant
(P<0.0001) decrease in average EDED score
between the initial visit and week 8 for both
treatment groups (Figure 2). Evaluators
were unable to determine treatment
success until at least the 6-week evaluation;
however, a trend did show improvement in
EDED score starting as early as day 15.