Page 3 - DHEA_BOOK

Dehydroepiandrosterone DHEA

Spayed / Neutered animals don't MAKE it but they benefit from it!!!

Recent investigations in lower mammals (Some of which do not secrete DHEA) have suggested that
DHEA (or its metabolites) may function as an anti‐obesity agent in these models of obesity independent
of food intake. Studies in humans have failed to demonstrate a beneficial effect of DHEA on body
composition or energy expenditure at either pharmacologic or physiologic replacement doses for 1‐3
months.

Dogs: The percent excess body weight (above ideal body weight) lost for the DHEA group was 65.7
versus 31.4 for the placebo group (P less than 0.02)

DHEA in Dogs can have an autoinflammatory Impact: The autoinflammatory reaction observed closely
resembles mevalonate kinase deficiency (MKD), a rare autosomal recessive disease in humans
characterized by recurrent febrile attacks, arthralgia, skin rash, and aphthous ulcers of mucocutaneous
tissues.

One of the most ill‐informed and dangerous sources of information I found during this browsing:
https://healthyandhappydog.wordpress.com/countering‐the‐effects‐of‐spay/
One offered DHEA dose: Administered orally in capsules at a dose of 60 mg/kg per day. (Divided)

Homeopathy is a huge, spinning mish‐mash of reckless, anecdotal, and unprofessional
recommendations and quotations from studies that, VERY often extrapolate from human research to
animal research. Fact checking is MISSING and lay‐authors especially trap themselves in tornadoes of
information and start drawing conclusions and relationships between cause and effect that eventually
mire down in absurdity and ineffectuality.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/j.1550‐8528.1998.tb00310.x

DHEA 10‐12 mg/lb twice a day

Effect of age and sex on plasma cortisol and dehydroepiandrosterone concentrations in the dog (Canis
familiaris) Limited data exist on age‐related physiological variations in plasma concentrations of cortisol
and dehydroepiandrosterone (DHEA) in dogs, despite their potential role in the pathophysiology of
ageing. This study examined plasma cortisol and DHEA concentrations and cortisol/DHEA ratio
variations, according to age and sex in 311 dogs, aged from two months to 16years. Before adulthood,
DHEA concentrations were higher in peri‐pubertal males. During adulthood, cortisol and DHEA were
higher in males than females. Among females, DHEA was lower in older dogs, but the decrease was
observed at an older age in intact than ovariectomised females. Variations in the cortisol/DHEA ratio
inversely reflected those of DHEA. Results indicate that testicles are an important source of DHEA in
males, and that DHEA is mainly secreted by the adrenal glands in females. The ovaries' contribution to
circulating DHEA appears to be limited, although it may partially compensate an age‐related decrease in
adrenal secretion.

Serum levels of DHEA and DHEA‐S increase with increasing doses. Doses above 50 mg/day result in
levels that are at or above the upper limit of normal for healthy young adults. At doses above 300
mg/day the increment of serum DHEA and DHEA‐S appears to reach a plateau.