Page 14 - Diet And Dementia Casein Antioxidants DHEA
P. 14

18

                   16
                   14

                   12
                  Number of cats  10                                       Non-responder

                    8
                                                                           Responder
                    6
                    4

                    2
                    0
                          _-Casozepine              Placebo



             Figure 3.  Effect of _-casozepine on successful resolution of behavioral signs of anxiety and stress compared to a
             placebo control. The treatment group had significantly more responders than the control group (P=0.02).





                   18
                   16

                   14
                   12
                  Global score  10                                         _-Casozepine

                    8

                    6                                                      Placebo
                    4

                    2
                    0
                      0          2           4          6          8
                                      Time (weeks)

             Figure 4.  Rate of improvement for total global behavioral score between _-casozepine and placebo. Rate of total
             global score was significantly better for the treatment group (P=0.003).



         CONCLUSION AND CLINICAL IMPORTANCE

         The study provides positive Grade 1 evidence for the efficacy of _-casozepine in the management of cats exhibiting behaviors
         attributable to stressful social environments.
   9   10   11   12   13   14   15