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In the presence of disease, if patients are
                                            not eating, it is much harder for them to

                                            heal, and much harder for us to treat the
                                            disease process.

                                                                                                   —Dr. Burney




                                            Veterinary Cooperative Oncology Group   Dr. Freeman: In heart failure, hyporexia
                                            (VCOG) has published a grading system for   and dysrexia are huge problems. I hear
                                            appetite. But there are at least 3 other   this all the time from owners who spend
                                            grading schemes that I have found. So   half their day trying to get their dog or
                                            pinpointing the incidence of inappetence   cat with heart failure to eat.
                                            is challenging. In the literature, it ranges
                                            from 20% to 80% in oncology, depending   Dr. Johannes: Many of my patients
                                            on the chemotherapy used, and 20% to   starting chemotherapy are suffering from
                                            50% in general.  In cancer, when chemo-  hyporexia or dysrexia. Gastrointestinal
                                                       2
          Patients might have a very        therapy is quite effective, we are killing off   lymphoma is probably the worst because
          treatable disease but the         a lot of tumor, which releases cytokines,   I don’t know if they’re not eating because
                                            further exacerbating the inappetence.  of the chemotherapy, because of the
          medications make them feel                                           disease, or both. Depending on the type
          bad, so the owners stop           Dr. Burney: The ultimate consequence   of chemotherapy, probably between
                                            of continuous inappetence  is death.   15% and 50% experience some level of
          treatment because they lose
                                            However, the prevalence of inappetence   inappetence. We expect to see it with
          faith that we can get a positive   is difficult to determine. In my practice   doxorubicin, but depending on the
          outcome.                          probably about 30% of patients have   patient, it’s even seen with vincristine
                                            some form of hyporexia or dysrexia, but   and cyclophosphamide. We need to
          —Dr. Cook                         the percentage is definitely not that high   emphasize to our clients what they may
                                            for anorexia. I can’t tell you how many   see and the importance of reporting
                                            times a client tells me, “Oh, Dr. Burney,   what they’re experiencing at home.
                                            my dog is not eating anything at all.” On
                                            questioning, I learn that just yesterday   Dr. Cook: Dogs with chronic pancreatitis
                                            he ate a Vienna sausage, a pig’s ear,    and diabetes frustrate me the most.
                                            and several cat treats––more than his   You’re dealing with not only inappetence
                                            caloric requirements, but low-quality or   but also with its complications and the
                                            inappropriate foods. In such cases, the   stressor of giving insulin. Clients quit
                                            consequences can be severe nevertheless.   giving the insulin, and then the patient
                                            Then, in the presence of disease, if   becomes ketotic. Or the patient will eat
                                            patients are not eating, it is much harder   something inappropriate and the
                                            for them to heal, and much harder for us   pancreatitis flares up. Other patients
                                            to treat the disease process. If they need   might have a very treatable disease but
                                            any medications or surgical procedure   the medications make them feel bad, so
                                            that might impact their appetite and they   the owners stop treatment because they
                                            already are not eating, it just makes it that   lose faith that we can get a positive
                                            much harder to help a patient get better.  outcome.

                                            Dr. Freeman: In one study we did with   Dr. Larson: Does your approach
                                            dogs with heart failure, appetite changes   change if faced with an acute
                                            were an important reason that owners   versus chronic condition associated
                                            ended up euthanizing their dogs. So not   with inappetence? And what’s the
                                            only is it bad in terms of the disease, but   impact when you do not yet have a
                                            it may be the reason owners give up.    diagnosis?

                                            Dr. Larson: Can you tell us more   Dr. Burney: Nutritional support is
                                            about inappetence in heart disease   incredibly important in all patients
                                            and other common conditions?       regardless of whether they have an acute


          2  clinician’s forum  February 2018
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